The 14-3-3 proteins in regulation of cellular metabolism
نویسندگان
چکیده
منابع مشابه
The 14-3-3 proteins in regulation of cellular metabolism.
Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that modulate cellular and whole body energy and nutrient homeostasis. Large scale screening for cellular binding partners of 14-3-3 has identified numerous proteins that participa...
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Protein phosphorylation is key to the regulation of many proteins. Altered protein activity often requires the interaction of the phosphorylated protein with a class of "adapters" known as 14-3-3 proteins. This review will cover aspects of 14-3-3 interaction with key proteins of carbon and nitrogen metabolism such as nitrate reductase, glutamine synthetase and sucrose-phosphate synthase. It wil...
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The aim of this study to review an overview of the current information on the structure of proteins 14-3-3 and their complexes, in addition to that it provides insights into the mechanisms of their functions. The 14-3-3 proteins are from families maintain regulatory molecules expressed in all eukaryotic cells. It was discovered before thirty years, it is attributes of 14-3-3 proteins are able t...
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So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2011
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2011.08.008